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Med Associates Inc
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Revvity
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Revvity
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MetaMorph Inc
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Synergistix
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Broad Institute Inc
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heidelberg engineering
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Nanonis GmbH
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Peak Performance Technologies Inc
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MetaMorph Inc
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MetaMorph Inc
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Image Search Results
Journal: EMBO Molecular Medicine
Article Title: KRAS signaling in malignant pleural mesothelioma
doi: 10.15252/emmm.202013631
Figure Lengend Snippet: RNA sequencing results (GEO dataset GSE94415) of KRAS G12D ;Trp53f / f mesothelioma (KPM) cells ( n = 3) compared with pleural mesothelial cells (PMC; n = 1 pooled triplicate). n denotes biological replicates, since pooled triplicate technical replicates from each cell line were sequenced. Unsupervised hierarchical clustering shows distinctive gene expression of KPM versus PMC. Volcano plot showing some top KPM versus PMC differentially expressed genes. KPM and PMC expression of classic mesothelioma markers (top) and top KPM versus PMC overexpressed genes (bottom). Gene set enrichment analysis, including enrichment score and nominal probability value of the 150 gene‐signature specifically over‐represented in human mesothelioma compared with other thoracic malignancies derived from 113 patients (GSE42977) within the transcriptome of KPM cells versus PMC shows significant enrichment of the human mesothelioma signature in KPM cells. Data information: In (C), data are presented as mean (columns) and 95% confidence interval (bars). P : probability, two‐way ANOVA. ns, *, **, and ***: P > 0.05, P < 0.05, P < 0.01, and P < 0.001, respectively, compared with PMC, Bonferroni post‐tests. Source data are available online for this figure.
Article Snippet: Gene set enrichment analysis (GSEA) was performed with the
Techniques: RNA Sequencing, Gene Expression, Expressing, Derivative Assay